UK researchers conducted a retrospective case-series study of four children diagnosed with solid cancers at age 16 or younger, aiming to assess the time to and survival following a second cancer diagnosis. In those who received radiotherapy for the initial cancer, the median time to a second primary cancer diagnosis was 13.3 years, with a median survival of 9.7 years. In contrast, for those who did not receive radiotherapy, the median time to a second cancer diagnosis was 25.1 years. The study suggests that radiotherapy in children with Li-Fraumeni Syndrome (LFS) following a first cancer diagnosis is linked to poorer outcomes and should only be considered when no other potentially curative treatment options are available.
