Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to a wide range of cancers. While p53 mutations help explain some cancer risks, they don’t fully account for the complex patterns seen in LFS. Recent research has found other genetic factors, like polymorphisms and telomere changes, that may influence cancer types, age of onset, and outcomes in LFS families. Understanding these factors can provide insights into LFS and other familial cancer syndromes.
Read Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135649/
