Reproductive Concerns

Once you know you are carrying a mutation with the TP53 , you may wonder what the possibility is of passing Li-Fraumeni syndrome on to a child. LFS is autosomal dominant, meaning that any parent with LFS has a 50% chance of passing the gene mutation to each or any children. Often, a diagnosis of LFS is given before or during childbearing years. For people with LFS, the decision to have children can be difficult and intensely personal, due to the possibility of passing LFS on to child or developing cancer as a parent. Some people with LFS have used options such as sperm/egg donors, or pre-implantation genetic diagnosis to ensure their children do not inherit this mutation. There are many qualified experts such as oncologists, genetic counselors and fertility specialists that can help provide valuable information if needed when making this decision.