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We are a community of Li‑Fraumeni syndrome families, researchers and care providers. We are the building blocks of a future without LFS.

LFS Association provides a wide range of information, advocacy, and vital resources for individuals and families with Li-Fraumeni syndrome. We are at the helm of a consortium of researchers and medical providers to advance research and promote optimal care for the LFS community.

Newly Diagnosed? Need Support?

Reach out to LFSA today to speak to a member of our support family!

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LFS Association Events

Climb for a Cure

June 1 @ 8:00 am - August 31 @ 5:00 pm

Stepping Up for a World Without Inherited Cancer Join the Li-Fraumeni Syndrome Association (LFSA) today and throughout the summer as we step out and Climb for a Cure for LFS. Across the globe, LFSA teams will

Hunt Fore A Cure Golf Classic

September 14 @ 8:00 am - 5:00 pm

Monday, September 14, 2026 Makefield Highlands Country Club Yardley, PA Tee up for a day that drives real impact. The Hunt Fore a Cure Golf Classic raises vital funds for families living with Li-Fraumeni syndrome (LFS),

REACH26

October 2 @ 8:00 am - October 5 @ 1:00 pm

8th International LFS Association Symposium Hosted by MD Anderson Cancer Center in partnership with the LiFE Consortium Our 8th International Li-Fraumeni Syndrome Association Symposium will be a hybrid event – both in-person and virtual – bringing

LFS RESOURCES & SUPPORT

FAMILY SUPPORT

We are the building blocks of a future without LFS. Together we will bridge the gap between patients and professionals who have the same goal.

Patient Support & Advocacy • Youth Program • Patient Toolkit

GLOBAL LFS RESEARCH NETWORK

MEDICAL & SCIENTIFIC RESOURCES

The LFSA has 10 international chapters headed by medical professionals, patients and advocates, as well as a global partnership of a consortium of care providers.

Research • Medical Expertise • Clinical Trials & Studies

Genetics matter. Know your family, know your genes.

LFS predisposes carriers to a diverse range of childhood and adult-onset cancers – some rare, often early onset. Most families with LFS have an inherited pathogenic variant in the TP53 gene – a tumor suppressor gene. Malfunctioning TP53 are involved with most all cancers in the general population.

Download The LFS Fact Sheet

Always at the Heart of What We Do

As families who have been affected by LFS, we all know the significant challenges we have faced and overcome. At the LFS Association we want to share hope, resilience and compassion to all of our LFS families. We are the Faces of LFS…we are LFS Strong.